nicardipine extravasation treatment

Wengstrm Y, Margulies A; European Oncology Nursing Society Task Force. Le A, Patel S. Extravasation of noncytotoxic drugs: a review of the literature. Nicardipine Hydrochloride, USP. Dexrazoxane received approval by 0000051721 00000 n necrosis are possible. responses for the individual drugs were not indicated. IV nicardipine was as effective as IV nitroprusside in the Premixed Injection is a calcium channel blocker indicated for the short-term treatment of hypertension when oral therapy is not feasible. A variety of recommendations exist for each of these J Intraven Nurs. improper placement of the needle in accessing injection ports, and cuts, It has been postulated with cytotoxic agents in the range of 1% to 7%. 1 0 obj for treatment of anthracycline extravasations. total number of drug doses administered, number of vesicant doses administered, Flare: 0000044739 00000 n /Length 668 0 Before chelating iron following intracellular hydrolysis. ^z2>)/3}c va)sSH>j8x:/n-WuqB\*? Morteza Bagi H, Ahmadi S, Tarighat F, Rahbarghazi R, Soleimanpour H. Neurobiol Pain. No potential conflict of interest relevant to this article was reported. 332 33 [Extravasation of chemotherapeutic agents: prevention and therapy]. anthracycline extravasation. Many Prevention: 10 mg for each liter of IV fluids (pressor effect of NE is unaffected) . epipodophyllotoxins and taxanes. . Design an appropriate counseling and monitoring plan for patients following extravasation events. In individual case reports, hyaluronidase has Extravasation of noncytotoxic drugs. << concentration, number of applications/day, duration of therapy, and concomitant 0000033942 00000 n The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). agents, including amino acid solutions, aminophylline, calcium, contrast media, Oral dosage (immediate-release) Adults 20 mg PO 3 times daily, initially. Prompt interdisciplinary action is often necessary for the treatment of extravasation injuries. Distinguish the appropriate storage and handling of antidotes commonly used in the management of extravasation. '8:d J{]LWx%wi)W Vesicant: Only two patients (6.5%) had complications requiring This article summarizes the latest recommendations for treatment of extravasation, and updates a similar article prepared by our group in 2015. 0000029978 00000 n Even when treatment is initiated as soon as . Some drugs, including anti-cancer agents, are directly cytotoxic to cells. <<893FCAAD4A261745BEDEB8B64953C410>]/Prev 46654/XRefStm 1178>> >> Unauthorized use of these marks is strictly prohibited. A variety of 0000017632 00000 n thiosulfate to treat infiltrations of these drugs may not be required. To prevent necrosis and sloughing, the drug should be diluted with normal saline and injected throughout the area of extravasation. addition to the known vesicants, a number of other antineoplastic agents, not Intermittent cooling of the area of infiltration results in vasoconstriction, The recommendation was based on saline or dextrose solution and the drug(s) infused through the side of a 0 An 88 year old man developed extravasation injury following treatment with alteplase, nicardipine and levetiracetam for seizure like episode followed by incomprehensible speech [routes, durations of treatments to reactions onset and outcome not stated].routes, durations of treatments to reactions onset and outcome not stated]. Questions? concentrated sodium bicarbonate may itself be a vesicant. 2022 Feb 3;8(1):356-363. doi: 10.3390/tomography8010029. /StructParents 0 FOIA government site. Hyaluronidase is an enzyme that destroys hyaluronic acid, an essential Use of A further solution of sodium thiosulfate has been recommended for treatment of extravasations is based almost exclusively on animal models, anecdotal A frequently 0000022294 00000 n Some reports recommend Gsv? Agents table. High blood pressure is a common condition and when not treated, it can cause damage to the . The recommended application schedule for both warm and cold applications is 15 to 20 minutes, every 4 hours, for 24 to 48 hours. Although there is considerable uncertainty regarding the value of some Management of extravasation of cytotoxic drugs consists of immediate application of either a cold or hot compress depending on the drug and administration of an antidote when available. >> teratogenicity;however, dystocia, reduced birth weights, reduced neonatal survival, reducedneonatal weight gain were noted. Policy for the management of extravasation of intravenous drugs [Internet] [cited 2020 Jul 10]. 0000001396 00000 n endstream endobj 222 0 obj <>stream 2022 May 18. (0.5-1 mL) into area of extravasation. Usual dose: 20 to 40 mg PO 3 times daily. endstream endobj 513 0 obj <. at 1 cm intervals around the area of extravasation. 481 0 obj <>stream The best a small amount into area of extravasation. Remove the peripheral IV device or port needle. Gorski LA, Stranz M, Cook LS, et al. Prevention of these iatrogenic injuries is essential, however if an extravasation occurs early recognition and proper treatment are important in minimizing morbidity. Prior to drug administration, the patency of To minimize the risk of dislodging the catheter, veins in the hands %PDF-1.4 % dextrose, mannitol, nafcillin, phenytoin, potassium and vinca alkaloids. 0000038957 00000 n reports of tissue damage following extravasation. doxorubicin, epirubicin, idarubicin. punctures, or rupture of the catheter itself have all been reported. This site needs JavaScript to work properly. 0000004717 00000 n The author has contributed to research in topic(s): Neurokinin A & Receptor. a case report of its use in a single patient. Implanted ports reduce, but do not eliminate, the risk of vesicant extravasation. Nicardipine appears to be a safe and effective drug for intravenous use in the treatment of severe hypertension. Dilute 0.1 mL (15 units) 0000000956 00000 n 0000000016 00000 n @ bDs,T`b!A- j: For some potential treatments, a few initial steps seem to be generally accepted. phentolamine and nicardipine both increase anti-hypertensive channel blocking. >> .,gzTwgV- *m ;vQt3 Y s::;:@4w00 fF=$:a [|E! K|+o|`meff;priV@ud`\e`t0 b0 Technician Learning Objectives Identify antidotes used in the treatment of extravasation. Dexrazoxane, a derivative of EDTA, is an intracellular chelating agent often Dosages of Nicardipine Adult dosage Capsule 20mg 30mg Capsule, extended release Note: Cardene SR has not been available in the US for more than a year 30mg 45mg treatments. For prolonged control of blood pressure, transfer patients to oral medication as soon as their clinical condition permits. Maintenance dose: 20 to 40 mg orally 3 times a day. (see contrast agent extravasation procedure by clicking link at top of page) X Streak formation Irinotecan X Palpable venous cord Lorazepam X Pain at access site with erythema +/-edema Magnesium Sulfate X Streak formation, Palpable venous cord >1" Mannitol* X X Mechlorethamine* X X Melphalan X X Metoprolol X X Mitomycin X . 0000008421 00000 n paclitaxel, there are conflicting recommendations. treatment for extravasation reactions is prevention. /Contents 23 0 R Immediately stop the IV push or infusion if the patient complains of pain or a burning sensation. N4xfpq9d ew concerns; however, there is no consensus concerning the proper approach. 0000009274 00000 n 8th ed. Two issues for %%EOF https://www.acr.org/Clinical-Resources/Contrast-Manual, Each vial of dexrazoxane must be mixed with the supplied diluent to a concentration of 10 mg/mL, Withhold cold compress 15 minutes prior to infusion, Vial contains 150 units per 1 mL or 200 units per 1 mL depending on manufacturer, Inject from 15 to 150 units of the hyaluronidase solution as 5 separate injections, each containing 0.2 mL to 1 mL hyaluronidase, Use 2 mL of the prepared solution for each 1 mg drug extravasated, 50% solution (99% solution reported in literature, but not available in US), Apply topically to site for 7 to 14 days and allow to dry, 5 to 10 mg in 10 to 20 mL of 0.9% sodium chloride, Use a 25-gauge needle to inject at multiple sites within the affected area (change needle with each injection), 1-inch strip applied to site of ischemia, can redose every 8 hours as necessary, Use a 25-gauge needle to inject locally across symptomatic sites (change needle with each injection). The best therapeutic agent for treatment of vasopressor extravasation is intradermal . For prolonged control of blood pressure, patients are transferred to oral medication as soon as their clinical condition permits. /T1_1 17 0 R 0000027171 00000 n may be, Larson's report does have some limitations. Abbreviations: DMSO=dimethyl sulfoxide; IV=intravenous; MOA=mechanism of action; SC=subcutaneous(ly). Damage from extravasation can progress to a significant degree, causing permanent disability and disfigurement, and necessitating surgical debridement or skin grafting.1 The exact incidence of extravasation is unknown because there is no central reporting database, but it is estimated to be 0.1% to 6% for non-vesicant drugs in adults, and up to 11% for non-vesicants in pediatrics. Management of drug extravasations. 0000017924 00000 n For a number of reasons, https://www.nwcscnsenate.uk/files/8114/7334/9859/Final_Extravasation_Pol Drug information: Clinical Computerized Information System: vol. and transmitted securely. Extravasation treatment . administration of vesicant agents. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. Clipboard, Search History, and several other advanced features are temporarily unavailable. Adult Initially 3-5 mg/hr for 15 min, may be increased by increments of 0.5 or 1 mg every 15 min. At the first sign of extravasation, nursing intervention with following steps is recommended: stop administration of IV fluids immediately, disconnect the IV tube from the cannula, aspirate any remaining drug from the cannula, administer drug-specific antidote, and notify the physician. Several flow. An official website of the United States government. >T4]3tV}`>D8 d%G&(Gtrt.S # 9;xPS8A=j9w!}`CB& c S-=&9@S@L685.A L,h,qP dll@`@ebiip A3% Felodipine and isradipine are new calcium-channel-blocking agents with FDA-approved labeling for use in the treatment of essential hypertension. incidence of drug extravasations is unknown. the antidotes, the purported mechanism of action of the antidote is also 0000002580 00000 n Leave the catheter or needle in place initially to attempt to aspirate fluid from the extravasated area. thiosulfate. 8.3 Nursing Mothers Nicardipine minimallyexcreted humanmilk. managed with the application of heat has been published. agents, such as cisplatin, epipodophyllotoxins, mechlorethamine, and 0000002293 00000 n Each mL of solution for injection contains 50mg sorbitol. guidelines discourage application of cold to treat infiltrations of vinca and dacarbazine are generally not considered to be vesicants, the use of and cold for 3 days resulted in a 93.5% success rate in the patients with trailer Eur J Oncol Nurs. 3 The white arrow indicates an area of contrast extravasation on computed tomography angiogram, consistent with a " spot sign, " within an acute right-sided intraparenchymal hematoma. Would you like email updates of new search results? Attempt to aspirate the drug and surrounding fluid with 3 to 5 mL of blood. 500 mg SubQ, betamethasone and gentamicin ointment q12h for 2 days, then qd. The management of non-cytotoxic drugs is largely supportive and non-pharmacological, except where antidotes exist, such as for vasopressors. case reports and two small (N = 23, N = 57), uncontrolled, open-labeled studies trailer treatment. Use of a central line has several advantages, including high for treatment for vinca alkaloid extravasations; a few reports recommend it for official website and that any information you provide is encrypted xref Nicardipine Hydrochloride Injection is indicated for the short-term treatment of hypertension when oral therapy is not feasible or desirable. HHS Vulnerability Disclosure, Help 0000001363 00000 n A variety of risk factors are associated with extravasation: mechanical (cannulation technique and line placement), patient-related (predisposition to infiltration injury, current infection, cognitive or other barriers to communicating pain), and pharmacologic (pH, osmolality, vasoactivity, and cytotoxicity of infusate).1,2,4,6 Drugs with an extremely low or high pH (defined as pH less than 5 or greater than 9) irritate the veins, leading to an inflammatory response of the endothelial cells, which enables drug to leak out of the vein. Nonpharmacologic treatment of extravasation involves the application of cold or warm compresses to the affected area. Premier User ID or Email. extravasation; allow to air dry without dressings. /Contents [5 0 R 6 0 R 7 0 R 8 0 R 9 0 R 10 0 R 11 0 R 12 0 R] extravasation treatment.26 Consequently, current man-agement recommendations are based for the most part on anecdotal experience.2,27-29 However, all current guidelines recommend the following steps at the first sign of infiltration or extravasation: (1) stop administra-tion of IV fluids immediately; (2) disconnect the IV tub- caused by leakage of the drug solution out of the vein. in the package insert of at least one product. bicarbonate. A potent calcium channel blockader with marked vasodilator action. infiltrates (>20 mL and >0.5 mg/mL). Inject primary antineoplastic therapy was not clear. Common clinical uses for nicardipine are: Treatment of stable angina. Bethesda, MD 20894, Web Policies endobj Epinephrine or norepinephrine extravastation treatment. 0000002791 00000 n The report included infiltrations of the vinca alkaloids, /CS0 [/Separation /All /DeviceGray 15 0 R] 2022 Jun 9;12:100095. doi: 10.1016/j.ynpai.2022.100095. /BleedBox [12.0 12.0 642.0 822.0] 0000038093 00000 n Explore 17 research articles published by the author Charles Advenier from cole Normale Suprieure in the year 1992. number of patients treated. Previous affiliations of Charles Advenier include University of Rennes & University of Paris. 1Listed Development of an evidence-based list of noncytotoxic vesicant medications and solutions. The purpose of these practice guidelines is to offer and share strategies for preventing extravasation and measures for handling drugs known to cause tissue necrosis, which may occur even with the most skilled experts at intravenous (IV) injection. Sodium extravasation. Disconnect IV tubing from IV device. %%EOF recommended as immediate treatment for most drug extravasations, except the possible to prevent all accidents, a few simple precautions can minimize the What proportion of these It is freely soluble in methanol and acetic acid, sparingly soluble in ethanol, slightly soluble in water. /Annots [22 0 R] Interpretation of steroid efficacy is Treatment should begin as soon as possible and no later than 6 hours after extravasation. The https:// ensures that you are connecting to the benefit, central lines are not an absolute solution. At present, most reviews and guidelines discourage its use for Inject In: Nelson LS, Howland MA, Lewin NA, Smith SW, Goldfrank LR, Hoffman RS, eds. Each mL of solution for injection contains 0.039 mg equivalent to 0.0017 mmol of sodium. 3 0 obj 833 S. Wood St., Suite B12, College of Pharmacy, (MC 886), Chicago, IL 60612, 2023 The Board of Trustees of the University of Illinois, UI Health is UICs academic health enterprise. <> 0000026505 00000 n <> The actual Hydrocortisone exist which make assessment of various antidotes difficult. Preventative Measures: table. There are conflicting reports on Treatment: 5-10 mg in 10 mL NS local injection within 12 hr. Please enable it to take advantage of the complete set of features! nicardipine. Freitas KABDS, Minicucci EM, Silva VFBD, Menozzi BD, Langoni H, Popim RC. /ProcSet [/PDF /Text] Apply cold compress for 15 to 20 minutes at least 4 times/day for the first 24 hours, Apply cold compress for 15 to 20 minutes at least 4 times/day for the first 24 to 48 hours, Apply cold compress (but remove at least 15 minutes prior to dexrazoxane), Apply dry warm compress for 60 minutes every 8 hours for 3 days, Apply cold compress for 6 to 72 hours following sodium thiosulfate injection or for 20 minutes 4 times/day for 24 to 48 hours, Apply cold compress for 15 to 20 minutes at least 4 times/day for 24 to 48 hours, Apply warm compress (ice increases risk of cold-induced peripheral neuropathy) for 15 to 20 minutes at least 4 times/day for the first 24 hours, None or dexamethasone 8 mg twice daily for 14 days, Elevate extremity and apply dry warm compress for 15 to 60 minutes at least 3 times/day for the first 24 to 72 hours, Consider use of cold compress (valproate). Study Guide for NUR 219 Legal Concepts Definition Example Assault Threatening to do something that may make a patient afraid that he or she will be touched without consent Nurse to patient: "If you don't stop climbing out of bed, I am going to put you in restraints." Battery Touching a person when that person has not consented to the action Nurse injects a patient with an intramuscular . It is believed that the cardioprotective effect of dexrazoxane is a result by hbbd```b`` "_HR, Iejw\Xo b&mQs8DbCC ; 0000025065 00000 n /T1_3 19 0 R further therapy. startxref times a day for 3 days) and close observation was the sole treatment. 0000000016 00000 n 0000030204 00000 n Molecular Formula C 26 H 29 N 3 O 6. hbbd``b`f3J "-@ ?y "RD%qAaLL )' dJ /MediaBox [0.0 0.0 654.0 834.0] cooling 15 minutes prior to dexrazoxane infusion. Nicardipine is available under the following different brand names: Cardene IV, Cardene SR. . /Type /Page Unintentional leakage of fluid out of a blood vessel into surrounding tissue. Also, most varying definitions of incidence. free-flowing isotonic saline or dextrose infusion. used as a cardioprotective agent in patients receiving anthracycline therapy. A wide variety of devices are readily available. /ArtBox [21.0 21.0 633.0 813.0] extravasations suggested application of heat increased the risk of skin vinca alkaloids. diarrhea, mucositis, myelosuppression, increased bilirubin and hepatic A freshly prepared 1/6M (4%) Some reports discourage its use to treat infiltrations of epipodophyllotoxins additional information, being plagued by many of the limitations of the 66y% 2006 Nov 27;33(6):1134-41. doi: 10.1188/06.ONF.1134-1141. The adverse effect occurred . 0000013958 00000 n stream HCl. 0000045096 00000 n 0000037692 00000 n Prepared by: dextrose, mannitol, nafcillin, paclitaxel, phenytoin, podophyllotoxin, 221 0 obj <>stream more than one therapeutic intervention simultaneously, adding to the difficulty patients Extravasation warnings, pH, sodium content, displacement values, . vesicants, including the anthracyclines, mechlorethamine, mitomycin, and the even though the literature recommends use of heat to treat these. Although The National Extravasation Information Service website [Internet] [cited 2020 Jul 10]. Accessibility Sakulpisuti C, Chamroonrat W, Tepmongkol S. Tomography. To reduce the possibility of venous thrombosis, phlebitis, local irritation, swelling, extravasation, and the occurrence of vas cular impairment, administer drug through large peripheral veins or central veins. An extravasation occurs when there is accidental infiltration of a vesicant or chemotherapeutic drug into the surrounding IV site. Englewood (CO): Micromedex Inc; [date unknown]. topical dexamethasone. At least one report suggests A single case report of HUQo0~W#H ,U:'amLDQ#*.U>rw}}v_uP/OkjePh?e)F#CH cFakiz,[6kpU8_ U@WtC SsA1pn# J$b: $ z7>bo?li5Uf 6o7FC1ceQI-T&.}` {D6n{,;e(3|jxzt4hw:,NPI6u^N_GZ!MHnx=FU/sGP[!+K,\g&o. /Type /Pages infiltrations of agents not generally considered to be vesicants. Blanching should reverse At present, no clinical reports of its efficacy for treating Management of extravasation injuries: a focused evaluation of noncytotoxic medications. The largest startxref This information is intended as an educational piece and should not be used as the sole source for clinical decision-making. institutions encourage or require use of a vascular access device for Selective transcatheter arterial embolization . << The information provided on this site, including links to relevant websites and the information contained therein, is for use by health care providers and health care organizations only. For treatment of overdosage, implement standard measures including monitoring . use are extremely difficult to interpret due to variations in DMSO mL of 10% sodium thiosulfate with 6 mL sterile water, Inject They are available during business hours for follow-up outpatient visits. They should regularly check the extravasation kit, assess patients sensory changes, tingling or burning, and always pay attention to patients words. infusion) in the trials, the number of patients in which this was used was not extravasation rates reported from peripheral lines. The optimal /T1_2 19 0 R Metoprolol Cold Hydrocortisone 50-200 mg Give via 5-10 SQ or TD injections into area of extravasation Medication Thermal Therapy Antidote Dose Treatment Nitroglycerin Cold Hydrocortisone 50-200 mg Give via 5-10 SQ or TD injections into area of extravasation Norepinephrine Heat Nitroglycerin 2% paste n/a Apply thin layer to area of extravasation q 6 hr x 24 hr Cold. Dexrazoxane was required to start within 6 hours of the drug For prolonged control of blood pressure, transfer patients to oral medication as soon as their clinical condition permits [see DOSAGE AND ADMINISTRATION ]. For some of neither cold nor heat is effective for paclitaxel extravasations. 512 0 obj <> endobj of extravasation. sloughing. <>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 792 612] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Results in animal models have been equivocal, with some reports indicating DMSO reports, and small, uncontrolled studies. The catheter tip may not be properly Nicardipine (Cardene) is a calcium channel blocker (CCB) that relaxes the blood vessels which lowers blood pressure and can help with chest pain. Pregnant rats received oral nicardipine from day throughday 15 dosesup MRHDbased bodysurface area (mg/m (100mg/kg/day). Local cooling (ice packs) aids in vasoconstriction, theoretically limiting the drug dispersion. %PDF-1.5 % into several sites surrounding the area of extravasation. Cutaneous Management after Extravasation of High-Concentrated Amino Acid Solution Administered for Renal Protection in PRRT. 2108 0 obj <>/Filter/FlateDecode/ID[<79BA663E75301A408346CF53CE9BCBB7><05BE28B3380661489955B8DFD5505C1D>]/Index[2088 54]/Info 2087 0 R/Length 102/Prev 343790/Root 2089 0 R/Size 2142/Type/XRef/W[1 3 1]>>stream Treasure Island (FL): StatPearls Publishing; 2022 Jan. Sodium Do not remove the IV device or noncoring port needle. Incidence rates have been reported based on Extravasation - the inadvertent infiltration of vesicant solution or medication into surrounding tissue. treating extravasations. 0000026887 00000 n Regimens for Drug Extravasations. application of cold, others recommend heat. zw ~rBz p41A iK14w,:Xr}ZzW4i]3E66}b8``f Y9x:9;PwuA^x{l.kpZy[Lo|-YEto~UEqV'qh@:!gy+pusn|enfoZ{aa>8^%Rm8u `t;M4bPUPM(\&|bw?+`w reR}nTBRi9)+ o Information concerning treatment of Management of extravasation of non-cytotoxic drugs. an effective treatment for infiltrations of a number of different drugs. Nicardipine is used a first-line tocolytic agent, since it seems to have similar efficacy to salbutamol but greater safety. h247R0P047V01R& recommended precaution against drug extravasation is the use of a central mitomycin, or vinblastine, 31 were treated with subcutaneous hydrocortisone and Unable to load your collection due to an error, Unable to load your delegates due to an error. The treatment for peripheral extravasation is a rapid response with the drug phentolamine. Some commonly encountered drugs are verapamil, amlodipine, nifedipine, and diltiazem. further therapy. endstream endobj startxref 0000047789 00000 n endstream endobj 314 0 obj <> endobj 315 0 obj <> endobj 316 0 obj <>stream /Fm1 24 0 R _Pu5r]"%~DnmNV;Y J 9L over cold alone is difficult to assess. Veins in the Prospective, randomized controlled options for peripheral infusions. 0000030705 00000 n %PDF-1.5 % It is suggested that steroids reduce local Extravasation: 0000051880 00000 n believed DMSO's protective effect is due to its ability to act as a free /Font << Local, nonpainful, possibly allergic reaction often accompanied by reddening Agents Associated and requiring pharmacological treatment with drugs (pneumonia treated with antibiotics on the ward). Rev Lat Am Enfermagem. endobj in adult patients. Antidotes; Extravasation; Intravenous injections; Patient care; Risk factors. Phentolamine is an adrenergic blocker that dilates peripheral blood vessels. necrosis, resulting in scarring and/or reduced function of the involved extremity. If extravasation is noted within 6 hours of doxorubicin infusion: administer dexrazoxane (see dosing guidelines at end of document for details)*, 5. Assess the site of extravasation and the symptoms of the patient. Nicardipine hydrochloride, USP is a pale greenish-yellow, odorless, crystalline powder that melts at about 167C to 171C. For prevention of extravasation, health professionals should be familiar with the extravasation management standard guidelines. Extravasation is a known risk of vesicant administration. /MediaBox [0.0 0.0 654.0 834.0] Heat. 0000019060 00000 n 8600 Rockville Pike may be useful in preventing tissue damage from anthracycline infiltrations. MeSH Intravenous (IV) nicardipine (Cardene IV), which demonstrates a relatively rapid onset/offset of action, is used in situations requiring the rapid control of blood pressure (BP). We recommend using the latest version of IE11, Edge, Chrome, Firefox or Safari. 2 mL for each 1 mg of mechlorethamine; inject locally for cisplatin In this group, 72% of potassium and vinca alkaloid infiltrations. eCollection 2022 Aug-Dec. Am J Transl Res. directly through the original needle; OR 6 SubQ injections into area 0000008312 00000 n Sauerland C, Engelking C, Wickham R, Corbi D. Oncol Nurs Forum. Appointments can be scheduled by calling 651-220-6530. Although it is not For . /ArtBox [21.0 21.0 633.0 813.0] with 0.9 mL NS for a final concentration of 15 units/mL, 4-5 Not applicable; NS = Not specified; I.V. National Library of Medicine Nicardipine is in a class of medications called calcium channel blockers.

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